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Validation of an electrospray ionization LC/MS/MS method for quantitative analysis of vincristine in human plasma samples

✍ Scribed by Romain Guilhaumou; Caroline Solas; Angelique Rome; Madeleine Giocanti; Nicolas Andre; Bruno Lacarelle


Book ID
108161115
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
292 KB
Volume
878
Category
Article
ISSN
1873-376X

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## Abstract A highly sensitive and specific LC‐MS/MS method has been developed and validated for the estimation of pramipexole (PPX) with 500Β Β΅L human plasma using memantine as an internal standard (IS). The API‐4000 was operated under multiple‐reaction monitoring mode (MRM) using the electrospray