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Validation of 19f-magnetic resonance determination of myocardial blood volume

✍ Scribed by Gerald A. Rottman; Robert M. Judd; Frank C. P. Yin

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
349 KB
Volume
34
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of ^19^F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and ^125^I‐albumin. Measurement of myocardial vascular volume by ^19^F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.

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