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Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI

✍ Scribed by Heynric B. Grotenhuis; Jos J.M. Westenberg; Paul Steendijk; Rob J. van der Geest; Jaap Ottenkamp; Jeroen J. Bax; J. Wouter Jukema; Albert de Roos

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 182 KB
Volume: 30
Category: Article
ISSN: 1053-1807
DOI: 10.1002/jmri.21886

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV~MRI~) with PWV determined from invasive intra‐aortic pressure measurements (PWV~INV~) and to test the reproducibility of the measurement by MRI.

Materials and Methods

PWV~MRI~ was compared with PWV~INV~ in 18 nonconsecutive patients scheduled for catheterization for suspected coronary artery disease. Reproducibility of PWV~MRI~ was tested in 10 healthy volunteers who underwent repeated measurement of PWV~MRI~ at a single occasion. Velocity‐encoded MRI was performed on all participants to assess PWV~MRI~ in the total aorta (Ao~total~), the proximal aorta (Ao~prox~), and the distal aorta (Ao~dist~).

Results

The results are expressed as mean ± SD, Pearson correlation coefficient (PCC), and intraclass correlation (ICC). Good agreement between PWV~MRI~ and PWV~INV~ was found for Ao~total~ (6.5 ± 1.1 m/s vs. 6.1 ± 0.8 m/s; PCC = 0.53), Ao~prox~ (6.5 ± 1.3 m/s vs. 6.2 ± 1.1 m/s; PCC = 0.69), and for Ao~dist~ (6.9 ± 1.1 m/s vs. 6.1 ± 1.0 m/s; PCC = 0.71). Reproducibility of PWV~MRI~ was high for Ao~total~ (4.3 ± 0.5 m/s vs. 4.6 ± 0.7 m/s; ICC = 0.90, P < 0.01), Ao~prox~ (4.3 ± 0.9 m/s vs. 4.7 ± 1.0 m/s; ICC = 0.87, P < 0.01), and Ao~dist~ (4.3 ± 0.6 m/s vs. 4.4 ± 0.8 m/s; ICC = 0.92, P < 0.01).

Conclusion

MRI assessment of aortic pulse wave velocity shows good agreement with invasive pressure measurements and can be determined with high reproducibility. J. Magn. Reson. Imaging 2009;30:521–526. © 2009 Wiley‐Liss, Inc.

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