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Validated method for the simultaneous determination of methadone and its main metabolites (EDDP and EMDP) in plasma of umbilical cord blood by gas chromatography–mass spectrometry

✍ Scribed by Panagiota D. Nikolaou; Ioannis I. Papoutsis; Julia Atta-Politou; Sotiris A. Athanaselis; Chara A. Spiliopoulou; Antony C. Calokerinos; Constantinos P. Maravelias

Book ID: 108160850
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 445 KB
Volume: 867
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2008.04.006

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## Abstract Vardenafil (VDN) is one of the three commercially available phosphodiesterase type 5 inhibitors and it is mainly used in the treatment of erectile dysfunction. A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method for the determination of VDN in blood has been dev