Improvements to vaccinia virus expression vectors continue to be made. In particular, there are new methods for the construction of recombinant viruses, ways of increasing the level of gene expression, and vectors that allow the inducible expression of selected genes.
β¦ LIBER β¦
Vaccinia and other poxvirus expression vectors
β Scribed by Bernard Moss
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 507 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0958-1669
No coin nor oath required. For personal study only.
β¦ Synopsis
Over the past year improvements have been made in recombinant vaccinia virus gene expression and a new method for inserting DNA into the poxvirus genome has been developed, along with alternative methods for selecting recombinant viruses. Attenuated and non-replicating vaccinia virus and avian poxvirus vectors are now being used successfully. Field trials of an oral, wild-life rabies vaccine and phase 1 testing of human vaccines derived from vaccinia virus are underway.
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