## BACKGROUND. We recently conducted a phase I clinical trial administering autologous dendritic cells pulsed with prostate-specific membrane antigen (PSMA) peptides to advanced prostate cancer patients. Participants were divided into 5 groups receiving 4 or 5 infusions of peptides alone (PSM-P1 o
Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA
✍ Scribed by Benoît Barrou; Gérard Benoît; Mahmoud Ouldkaci; Olivier Cussenot; Margarita Salcedo; Sudhanshu Agrawal; Séverine Massicard; Nadège Bercovici; MatsL. Ericson; Nicolas Thiounn
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 224 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0340-7004
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## Abstract Prostate stem cell antigen (PSCA) and prostate‐specific antigen (PSA) are overexpressed in most prostate cancers. PSCA‐ and PSA‐derived, HLA‐A2 binding peptides are specific targets for T‐cell responses __in vitro.__ A phase I/II trial was performed to demonstrate feasibility, safety an
## Background: A phase ii trial was conducted to assess the efficacy of infusions of dendritic cells (dc) and two hla-a2-specific psma peptides (psm-p1 and -p2). this report describes thirty three subjects with hormone-refractory metastatic prostate cancer without prior vaccine therapy history who