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UVB and UVA Initiate Different Pathways to p53-Dependent Apoptosis in Melanocytes

✍ Scribed by Noonan, Frances P; De Fabo, Edward C


Book ID
109875367
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
73 KB
Volume
129
Category
Article
ISSN
0022-202X

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p53-Dependent DNA repair and apoptosis r
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p53 plays an essential part in the maintenance of the cellular genetic stability after a DNA-damaging event such as ultraviolet (UV) radiation. Following UV radiation, the amount of p53 protein is elevated. The increased p53 is believed to induce cell cycle arrest, promote nucleotide excision repair