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UV mutation signature in tumor suppressor genes involved in skin carcinogenesis in xeroderma pigmentosum patients

✍ Scribed by D'Errico, Mariarosaria; Calcagnile, Angelo; Canzona, Flora; Didona, Biagio; Posteraro, Patrizia; Cavalieri, Rino; Corona, Rosamaria; Vorechovsky, Igor; Nardo, Tiziana; Stefanini, Miria


Book ID
110062667
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
230 KB
Volume
19
Category
Article
ISSN
0950-9232

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## Abstract By using PCR amplification and oligonucleotide mismatch hybridization, base‐substitution mutations of the __ras__ genes in 26 skin tumors of Japanese xeroderma pigmentosum (XP) patients were studied. Thin sections of tumor tissues which were fixed and embedded in paraffin blocks were us