✦ LIBER ✦

Infrequent mutation of the ras genes in skin tumors of xeroderma pigmentosum patients in Japan

✍ Scribed by Kanji Ishizaki; Tohru Tsujimura; Masanao Nakai; Chikako Nishigori; Kenji Sato; Shoichi Katayama; Osamu Kurimura; Kunihiko Yoshikawa; Sadao Imamura; Mituo Ikenaga

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 700 KB
Volume: 50
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910500309

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

By using PCR amplification and oligonucleotide mismatch hybridization, base‐substitution mutations of the ras genes in 26 skin tumors of Japanese xeroderma pigmentosum (XP) patients were studied. Thin sections of tumor tissues which were fixed and embedded in paraffin blocks were used in this study. After analyzing codons 12, 13 and 61 of the H‐, K‐ and N‐ras genes by using 66 oligomer probes, we detected only one mutation of the K‐ras gene at codon 61 in one tumor sample. All the other tumors were therefore considered not to have a mutation in the ras genes. These results suggest that mutations of the ras genes are not particularly associated with skin tumors of Japanese XP patients.

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