Utilization of variant-type of human α-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma
✍ Scribed by Ishikawa, H; Nakata, K; Mawatari, F; Ueki, T; Tsuruta, S; Ido, A; Nakao, K; Kato, Y; Ishii, N; Eguchi, K
- Book ID
- 110038388
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 98 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0969-7128
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For an approach of gene therapy for hepatocellular carcinoma (HCC), transcriptional regulatory sequence (TRS) of either alpha-fetoprotein (AFP) or albumin has been used for targeting cancer cells. To examine the feasibility of using TRSs of these genes for possible gene therapy of HCCs, the cellular
## HEY-CHI Hsu2 The messenger RNA and DNA methylation of the a-fetoprotein gene were studied in 101 resected primary hepatocellular carcinomas, of which 93 were unicentric and 8 were multicentric. Fifty-five were 5 cm or less in diameter (small) and 46 were more than 5 cm in diameter (large). In 4