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Utilization of Fukuyama’s sulfonamide protecting group for the synthesis of N-substituted α-amino acids and derivatives

✍ Scribed by Xiaodong Lin; Hilary Dorr; John M. Nuss

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
206 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel and general route for the solid phase synthesis of N-substituted α-amino acids has been developed. This synthesis employs Fukuyama's 2-nitrobenzenesulfonamide protecting group for preparation of secondary amines. The versatility of this methodology is demonstrated by the facile synthesis of a trisubstituted diketopiperazine (DKP) skeleton.

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