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The mass spectra of amino-acid and peptide derivatives—III:. A comparison of the utility of various N-protecting groups

✍ Scribed by R. T. Aplin; I. Eland; J. H. Jones

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
249 KB
Volume
2
Category
Article
ISSN
1076-5174

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✦ Synopsis

Comparison of the acetyl-, trifluoroacetyl-, benzyloxycarbonyl-, rnethoxycarbonyl-, ethoxycarbonyl, methylaminocarbonyl, phenylaminocarbonyl-, phthaloyl-and stearoyl-derivatives of glycyileucylphenylalanine rnethyl ester has shown that the acetyl derivative is the most volatile. The relative abundances of the sequence ions in the m a s spectra of these compounds have been determined and compared : the acetyl derivative provides the best combination of volatility and abundance of sequence ions. Evidence is presented to show that the use of acid-catalysed esterification procedures for the chemical modification of peptides prior to m a s spectrometric investigation can lead to degraded derivatives.

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