Utilization of a 1-cyclobutenylphosphine oxide as a 2-phosphinyl-1,3-butadiene synthon. Synthesis of functionalized 1-phosphinylcyclohexenes
β Scribed by Minami, Toru; Chikugo, Tsuguhiko; Hanamoto, Takeshi
- Book ID
- 121681691
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 634 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Pictet-Spengler condensation of b-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1%-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated.
1-Benzyldimethylsilyl-4-phenylthio-1,3-butadiene (L), prepared by hydrosilation of propargyl alcohol, oxidation and followed by Wittig-Horner reaction, underwent Diels-Alder reaction with methyl methacrylate. The adduct after oxidation to the sulfone when treated with fluoride gave 5-carbomethoxy-5-