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Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline

✍ Scribed by Michèle Bois-Choussy; Sébastien Cadet; Michaël De Paolis; Jieping Zhu

Book ID: 104230841
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 123 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00776-6

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✦ Synopsis

Pictet-Spengler condensation of b-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1%-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated.

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## Abstract For Abstract see ChemInform Abstract in Full Text.