Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection
β Scribed by Frank-Peter Theil; Theodor W Guentert; Sami Haddad; Patrick Poulin
- Book ID
- 119537472
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 1004 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0378-4274
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π SIMILAR VOLUMES
Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from six chemical classes. Input data consisted of structure based predictions of lipophilicity, ionization, and
The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib
Many in vitro data on physicochemical properties and specific absorption, distribution, metabolism, and elimination (ADME) processes are already available at early stages of drug discovery. These data about new drug candidates could be integrated/ connected in physiologically based pharmacokinetic (