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Utility of Gene Promoter Methylation in Prediction of Response to Platinum-Based Chemotherapy in Epithelial Ovarian Cancer (EOC)

✍ Scribed by Chaudhry, Parvesh; Srinivasan, Radhika; Patel, Firuza D.

Book ID
121420938
Publisher
Informa plc
Year
2009
Tongue
English
Weight
308 KB
Volume
27
Category
Article
ISSN
0735-7907

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## Abstract Epithelial ovarian cancer (EOC) is treated mainly by platinum‐based combination chemotherapy. Chemotherapy induces apoptosis in which the Fas/Fas ligand pathway is important. Serum soluble Fas (sFas) is a biomarker of this pathway and functionally inhibits Fas‐/FasL‐mediated apoptosis.