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Speed of response to platinum-based chemotherapy: Implications for the management of epithelial ovarian cancer

✍ Scribed by Lawton, Frank G.; Kelly, Krystyna A.; Sant Cassia, Louis J.; Blackledge, George

Book ID
122620237
Publisher
Elsevier Science
Year
1987
Weight
482 KB
Volume
23
Category
Article
ISSN
0277-5379

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## Abstract Epithelial ovarian cancer (EOC) is treated mainly by platinum‐based combination chemotherapy. Chemotherapy induces apoptosis in which the Fas/Fas ligand pathway is important. Serum soluble Fas (sFas) is a biomarker of this pathway and functionally inhibits Fas‐/FasL‐mediated apoptosis.