Utiliry of Cyanoacetamide and Cyanothioacetamide in Heterocyclic Synthesis
✍ Scribed by Mourad Sherif, Sherif; Mohamed Abdel-Galil, Fathy; Hilmy Elnagdi, Mohamed
- Book ID
- 118255642
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 1986
- Tongue
- English
- Weight
- 404 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0385-5414
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## Abstract Cyanoacylation of 2‐amino‐tetrahydrobenzothiophene‐3‐carboxylate ethyl ester with 3‐(3,5‐dimethyl‐1__H__‐pyrazol‐1‐yl)‐3‐oxopropanenitrile afforded cyanoacetamide **2**. The later was utilized as key intermediate for the synthesis of 3‐substituted 2‐iminocoumarins **3**, **4**, **5**, *
## Abstract The reaction of α‐cyanothioacetamide (1) or its methylthio derivative (2) with anthranilic acid led to the formation of 3,4‐dihydro‐4‐oxoquinazolin‐2‐yl acetonitrile (3). 3 condensed with aromatic aldehydes to give arylidene derivatives (4a‐d) which could be prepared also via the reacti