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Uterine estrogen receptor binding of catecholestrogens and of estetrol (1,3,5(10)-estratriene-3,15α,16α,17β-tetrol)

✍ Scribed by Charles Martucci; Jack Fishman


Book ID
118978215
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
462 KB
Volume
27
Category
Article
ISSN
0039-128X

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Preparation of tritium labelled estetrol
✍ Jack Fishman; Henry Guzik 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 French ⚖ 242 KB

## Abstract The preparation of the tritium labelled fetal metabolite estra‐1, 3, 5 (10)‐3, 15α, 16α, 17β‐tetrol 6,7‐^3^H is described. The material was prepared by oxidation of the tetrol tetraacetate lb to the 6‐keto derivative II. Reduction of the 6‐ketone to the 6‐hydroxy compound III and dehydr

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A new metabolite derived from estradiol and considered to be exclusively fetal in origin was obtained from neonatal and pregnancy urine by Hagen et al' and Gurpide et a12. The compound contained four acylable hydroxy functions and formed an acetonide derivative. One tentative structure suggested was