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Preparation of tritium labelled estetrol [estra-1,3,5(10)- triene-3,15α,16α,17β- tetrol 6,7-3H]

✍ Scribed by Jack Fishman; Henry Guzik

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
242 KB
Volume
6
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of the tritium labelled fetal metabolite estra‐1, 3, 5 (10)‐3, 15α, 16α, 17β‐tetrol 6,7‐^3^H is described. The material was prepared by oxidation of the tetrol tetraacetate lb to the 6‐keto derivative II. Reduction of the 6‐ketone to the 6‐hydroxy compound III and dehydration with dimethylsulfoxide gave the Δ6 derivative III. Reduction of III with tritium followed by hydrolysis gave the tetrol‐^3^H with a specific activity of 43 curies/mmole.

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