Use of topical liposomes containing meglumine antimoniate (Glucantime) for the treatment of L. major lesion in BALB/c mice

✍ Scribed by Moosavian Kalat, S.A.; Khamesipour, A.; Bavarsad, N.; Fallah, M.; Khashayarmanesh, Z.; Feizi, E.; Neghabi, K.; Abbasi, A.; Jaafari, M.R.

• Book ID: 122275940
• Publisher: Elsevier Science
• Year: 2014
• Tongue: English
• Weight: 541 KB
• Volume: 143
• Category: Article
• ISSN: 0014-4894
• DOI: 10.1016/j.exppara.2014.04.013

✦ Synopsis

h i g h l i g h t s

Topical liposomal Glucantime reduced lesion sizes in BALB/c model of leishmaniasis. The spleen parasite burden was significantly lower in the groups treated with TLG. Oleic acid in liposomal formulation did not increase the effect of the treatment. TLG could be a good candidate for topical treatment of cutaneous leishmaniasis.