Kinetics of drug action in disease state
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Patricia M. Klockowski; Gerhard Levy
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Article
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1987
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John Wiley and Sons
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English
โ 512 KB
Computer simulations were performed to determine if the threshold dose of an infused drug (rather than the drug concentration in the biophase at onset of action) can be a suitable index for pharmacodynamic investigations as proposed by others. A two-compartment pharmacokinetic model with drug elimin