✦ LIBER ✦

Use of statistical measures for analyzing RNA secondary structures

✍ Scribed by Qi Dai; Tian-Ming Wang

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 436 KB
Volume: 29
Category: Article
ISSN: 0192-8651
DOI: 10.1002/jcc.20891

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✦ Synopsis

Abstract

With more and more RNA secondary structures accumulated, the need for comparing different RNA secondary structures often arises in function prediction and evolutionary analysis. Numerous efficient algorithms were developed for comparing different RNA secondary structures, but challenges remain. In this article, a new statistical measure extending the notion of relative entropy based on the proposed stochastic model is evaluated for RNA secondary structures. The results obtained from several experiments on real datasets have shown the effectiveness of the proposed approach. Moreover, the time complexity of our method is favorable by comparing with that of the existing methods which solve the similar problem. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2008

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