The guide "Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Dosage Forms Containing Certain Active Moieties/Active Ingredients Based on a Biopharmaceutical Classification System" (Rockville, MD: CDER, 2000) outlined non-in vivo tests of permeability that may s
β¦ LIBER β¦
Use of simultaneous computer fitting to estimate the apparent absorption rate constant
β Scribed by Kenneth R. Brouwer; Patrick J. McNamara
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 377 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3549
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Some authors have used an elimination rate constant derived from one theophylline treatment (e.g. the elixir) to apply the Wagner-Nelson method to concentration-time data from another treatment (e.g. a sustained-release form). Since there is considerable intrasubject variation in the elimination rat