Use of proton MR spectroscopy and MR imaging to assess obesity

✍ Scribed by Mario Barac-Nieto; Raj K. Gupta

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 439 KB
• Volume: 6
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1880060141

✦ Synopsis

We used ' H MR spectroscopy and M R imaging at 9.4-T to quantify and localize fat and water in the abdominal regions of 12 lean, normal, and obese mice. The D . 0 dilution method which measures also the equilibrium plasma D . 0 concentration by M R spectroscopy was used to quantify body water and fat. In obese mice, the intensity of the fat ' X i resonance waa abont 120% that of the water ' H reM)nance. about threefold higher than its value (about 45%) in normal mice. In lean mice. the fat/water intensity ratio was about 1:4, about half that in normal mice. Total body water was similar in obese and normal mice (19.9 k 1.5 and 18.7 & 1.3 mL) despite their very Merent body weights (50.1 & 3.1 g and 30.2 ? 3.1 g, respectively), but slightly lower in lean mice (14.8 & 1.2 mL water: 22.1 g k 2.0 g weight). Selective =ethylene-proton images showed marked accumdation of fat in the abdomen and the retroperitoneal and subcutaneous spaces of obese mice. Selective water-proton imagea allowed clear resolution of the renal cortex, medulla. papilla, and urinary pelvis. The readily measurable resonance intenmity ratio of abdominal fat to water is a sensitive index by which to characterfie obesity. I Index tern: Obesity * Magnetic resonance spectroscopy * Magnetic resonance imaging * Nuclear magnetic resonance -Body composition * Body fat * Abdominal fat