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Use of precision-cut renal cortical slices in nephrotoxicity studies

✍ Scribed by Baverel, Gabriel; Knouzy, Burhan; Gauthier, Catherine; El Hage, Maha; Ferrier, Bernard; Martin, Guy; Duplany, Agnès

Book ID
120654864
Publisher
Informa plc
Year
2012
Tongue
English
Weight
960 KB
Volume
43
Category
Article
ISSN
0049-8254

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✍ H. J. Toutain; J. P. Sarsat; A. Bouant; D. Hoet; D. Leroy; V. Moronvalle-Halley 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 889 KB

The dog is the non-rodent species the most often used in preclinical drug safety evaluation. In this study, we established a new system of precision-cut dog renal cortical slices, evaluated their biochemical, functional, and morphological integrity, and determined the effects of cisplatin (cisdiammi