𝔖 Bobbio Scriptorium
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Use of precision-cut liver slices for studies of unscheduled DNA synthesis

✍ Scribed by J.A. Beamand; R.J. Price; S.D. Blowers; P.T. Wield; M.E. Cunninghame; B.G. Lake


Book ID
119160858
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
749 KB
Volume
32
Category
Article
ISSN
0278-6915

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## Abstract Early detection of kinetic, metabolic, and toxicity (ADME‐Tox) profiles for new drug candidates is of crucial importance during drug development. This article describes a novel in vitro system for the incubation of precision‐cut liver slices (PCLS) under flow conditions, based on a poly