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Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers

✍ Scribed by PRICE, R. J.; BALL, S. E.; RENWICK, A. B.; BARTON, P. T.; BEAMAND, J. A.; LAKE, B. G.


Book ID
125508248
Publisher
Informa plc
Year
1998
Tongue
English
Weight
246 KB
Volume
28
Category
Article
ISSN
0049-8254

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## Abstract Early detection of kinetic, metabolic, and toxicity (ADME‐Tox) profiles for new drug candidates is of crucial importance during drug development. This article describes a novel in vitro system for the incubation of precision‐cut liver slices (PCLS) under flow conditions, based on a poly