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Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

✍ Scribed by de Graaf, Inge A M; Olinga, Peter; de Jager, Marina H; Merema, Marjolijn T; de Kanter, Ruben; van de Kerkhof, Esther G; Groothuis, Geny M M

Book ID
109946798
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
975 KB
Volume
5
Category
Article
ISSN
1750-2799

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## Abstract Early detection of kinetic, metabolic, and toxicity (ADME‐Tox) profiles for new drug candidates is of crucial importance during drug development. This article describes a novel in vitro system for the incubation of precision‐cut liver slices (PCLS) under flow conditions, based on a poly