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Use of phased array coils for a determination of absolute metabolite concentrations

โœ Scribed by Oliver Natt; Vitaliy Bezkorovaynyy; Thomas Michaelis; Jens Frahm


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
436 KB
Volume
53
Category
Article
ISSN
0740-3194

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โœฆ Synopsis


Abstract

This work describes the use of phased array coils for a quantification of absolute metabolite concentrations. The method is demonstrated for singleโ€voxel localized proton MRS of human brain with an eightโ€element receiveโ€only head coil. It is based on the transmitter reference amplitude of the body coil used for RF transmission. A relative sensitivity of every element of the phased array coil is derived from a combination of two reference scans without water suppression that correspond to either the body coil in transmitโ€receive mode or the phased array coil in conjunction with body coil excitation. Experimental results were obtained at 2.9 T for both phantoms and 12 human subjects in different locations of gray and white matter. The data demonstrate that the procedure is technically robust and without a penalty in measuring time. Moreover, it takes full advantage of the signalโ€toโ€noise gain for quantitative proton MRS and may be extended to other phased array coils without the need for a recalibration. Magn Reson Med 53:3โ€“8, 2005. ยฉ 2004 Wileyโ€Liss, Inc.


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