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Comparison of methods for the determination of absolute metabolite concentrations in human muscles by 31P MRS

✍ Scribed by Reto Buchli; Professor Peter Boesiger

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
739 KB
Volume
30
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

In order to determine metabolite concentrations in human skeletal muscles by in vivo ^31^P MRS, different quantification methods were analyzed with regard to the accuracy and reproducibility of results and the simplicity of handling. Each quantification method comprised a calibration strategy and a localization technique. Extensive in vivo and in vitro tests showed that homonuclear phantom‐based calibration strategies yielded significantly more accurate (lower systematic errors) and more reproducible (lower statistical errors) concentration estimates than heteronuclear strategies using internal water as a concentration standard. Additionally, the former strategies are easier to handle than the latter. Localization with the volume‐selective sequence lSlS yielded slightly more reproducible results than localization by surface coil. We conclude that phosphorus metabolite concentrations are determined most accurately with phantom‐based calibration strategies in combination with lSlS localization (measurement errors β‰ˆ 5–7%).

πŸ“œ SIMILAR VOLUMES

Assessment of absolute metabolite concen
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