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Use of p53 for therapy of human cancer

✍ Scribed by V. P. Almazov; D. V. Kochetkov; P. M. Chumakov

Book ID
110174505
Publisher
SP MAIK Nauka/Interperiodica
Year
2007
Tongue
English
Weight
197 KB
Volume
41
Category
Article
ISSN
0026-8933

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## Abstract ## Background. In the majority of human cancers, the tumor suppressor activity of p53 is impaired because of mutational events or interactions with other proteins (ie, MDM2). The loss of p53 function is responsible for increased aggressiveness of cancers, while tumor chemoresistance an