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Use of nonproteases in peptide synthesis

✍ Scribed by J.Blair West; Chi-Huey Wong

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
232 KB
Volume
28
Category
Article
ISSN
0040-4039

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✦ Synopsis

Practical procedures have been developed for synthesis of peptides using lipases and esterases as catalysts.

We describe here a new strategy for enzymatic peptide synthesis using an esterase without amidase activity as a catalyst and N-acyl amino acid esters and amino acid esters as substrates in ether or ethyl acetate containing 5-10% aqueous buffer or in pyridine as solvent.

A number of proteases have been used as practical catalysts in peptide 1 synthesis , particularly in synthesis of small peptides. Their applications so far,

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Use of carbonylditriazole in peptide syn
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✍ H. C. Beyerman; W. Maassen van Den Brink πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 201 KB

## Abstract __N,N__′‐Carbonyldi‐s‐triazole is shown to be a useful peptide‐forming reagent. Advantages over other reagents are: (1) low degree of racemization, (2) applicability in dimethylformamide, a solvent for both small and large peptides.