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Use of new phosphonylating and coupling agents in the synthesis of oligodeoxyribonucleotides via the H-phosphonate approach

✍ Scribed by Osamu Sakatsume; Hiroshi Yamane; Hiroshi Takaku; Naoki Yamamoto

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 225 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)93898-5

No coin nor oath required. For personal study only.

✦ Synopsis

Tris(l,l,l,

) phosphite was used as a phosphonylatin E reaEent for the preparation of nucleoside 3'-H-phosphonate units. The use of a new couplin E reaEent, 1,3-dimethyl-2-chloro-imidazolinium chloride (DMCI) for the internucleotidic H-phosphonate bond formation via the H-phosphonate approach is also discussed in detail.

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