Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies
β Scribed by SCHIELEN, WIM J.G. ;ADAMS, HANS P.H.M. ;NIEUWENHUIZEN, WILLEM ;TESSER, GODEFRIDUS I.
- Book ID
- 115099180
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 531 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0367-8377
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2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) has been adapted for use as a coupling reagent for tert-butyloxycarbonyl (Boc) amino acids in automated solid-phase peptide synthesis. When compared to the existing preformed symmetrical anhydride procedure employing dicycl
Part of the projected Ph. D. thesis of A. T., ETH Zurich. For reviews addressing the problem of solvation in solid-phase peptide synthesis, see [l] [2]. ## ') For Li-salt effects on peptide reactions in solution, see the accompanying paper [32] 'O) \*') '(PDMAA-KG resin)' stands for '{ { { 2-{ [4