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Lithium-Salt Effects in Peptide Synthesis. Part II. Improvement of Degree of Resin Swelling and of Efficiency of Coupling in Solid-Phase Synthesis

✍ Scribed by Adrian Thaler; Dieter Seebach; Francis Cardinaux

Publisher
John Wiley and Sons
Year
1991
Tongue
German
Weight
1007 KB
Volume
74
Category
Article
ISSN
0018-019X

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✦ Synopsis

Part of the projected Ph. D. thesis of A. T., ETH Zurich. For reviews addressing the problem of solvation in solid-phase peptide synthesis, see [l] [2].

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For Li-salt effects on peptide reactions in solution, see the accompanying paper [32] 'O) *') '(PDMAA-KG resin)' stands for '{ { { 2-{ [4-(oxymethyl)phenyloxy]a~~amido}pentanamido}ethylamino}poly(N,N-dimethylacrylamide) on 'Kieselgur'}', see D in the Scheme.

📜 SIMILAR VOLUMES

Lithium-Salt Effects in Peptide Synthesi
Lithium-Salt Effects in Peptide Synthesis. Part I. Conditions for the Use of Lithium-Salts in Coupling Reactions
✍ Adrian Thaler; Dieter Seebach; Francis Cardinaux 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 German ⚖ 679 KB

## Abstract The influence of Li‐salts on the course of peptide‐coupling reactions was investigated. As a model for segment couplings, Ac‐Phe‐OH was coupled to HCl·H‐Ala‐OMe using the mixed anhydride, DCC1, DCCl/HOBt, BOP‐__Castro__ and TBTU‐__Knorr__ methods. As a model for stepwise synthesis Z‐Phe