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Use of molecularly imprinted polymers in a biotransformation process

✍ Scribed by Lei Ye; Olof Ramström; Richard J. Ansell; Mats-Olle Månsson; Klaus Mosbach

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
97 KB
Volume
64
Category
Article
ISSN
0006-3592

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✦ Synopsis

Molecularly imprinted polymers are highly stable and can be sterilised, making them ideal for use in biotransformation process. In this communication, we describe a novel application of molecularly imprinted polymers in an enzymatic reaction. The enzymatic condensation of Z-L-aspartic acid with L-phenylalanine methyl ester to give Z-L-Asp-L-Phe-OMe (Z-aspartame) was chosen as a model system to evaluate the applicability of using molecularly imprinted polymers to facilitate product formation. When the product-imprinted polymer is present, a considerable increase (40%) in product yield is obtained. Besides their use to enhance product yields, as demonstrated here, we suggest that imprinted polymers may also find use in the continuous removal of toxic compounds during biochemical reactions.

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