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Use of mesna to prevent ifosfamide-induced urotoxicity

✍ Scribed by Lillian L. Siu; M. J. Moore

Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
190 KB
Volume
6
Category
Article
ISSN
0941-4355

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High-dose alkylation therapy using ifosfamide infusion with mesna in the treatment of adult advanced soft-tissue sarcoma
✍ Robin C. Stuart-Harris; Peter G. Harper; Colin A. Parsons; Stanley B. Kaye; Caro πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 463 KB

In a phase II study, 42 patients with advanced soft-tissue sarcoma were treated with ifosfamide by 24-h infusion and mesna by 4-h IV bolus, repeated every 3 weeks. Ten patients received ifosfamide 5.0 g/m2, 20 had the dosage increased to 8.0 g/m2, and 12 received 8.0 g/m2 from the outset. Mesna was