Use of indium-111-labeled OC-125 monoclonal antibody in the detection of ovarian cancer
β Scribed by RE Hunter; P Doherty; TW Griffin
- Book ID
- 118888425
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 137 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0020-7292
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Monoclonal antibody (MAb) O C 125 binds to approximately 80% of epithelial ovarian cancers. Serum antigen, CAI25, can be detected in these patients. "'I-OC 125-F(ab')2 was injected into 5 ovarian carcinoma patients with preinjection serum levels of I50 to 9,000 CAI25 U/ml. Patients received the anti
Ovarian cancer is a highly malignant tumor of mainly postmenopausal women. The long-term prognosis of this malignancy is largely determined by micrometastasis present at the time of second-look surgery. In general, patients face a poor outcome. New radio-immunoscintigraphic methods to target tumor t