In vitro assessment of cytochrome P450 i
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Lin, Tong (author);Pan, Kristine (author);Mordenti, Joyce (author);Lin, Pan (aut
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Article
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2007
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John Wiley and Sons Inc.
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English
β 153 KB
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A fast and robust LC/MS-based cytochrome P450 (CYP) inhibition assay, using human liver microsomes, has been fully developed and validated for the major human liver CYPs. Probe substrates were phenacetin, diclofenac, S-mephenytoin, and dextromethorphan for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, respec