Use of diclofenac in children with asthma

✍ Scribed by J. A. Short; C. A. Barr; C. D. Palmer; J. M. Goddard; C. G. Stack; R. A. Primhak

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 73 KB
• Volume: 55
• Category: Article
• ISSN: 0003-2409
• DOI: 10.1046/j.1365-2044.2000.01280.x

✦ Synopsis

This study investigated the effect of diclofenac on the lung function of 70 children aged 6–15 years with a diagnosis of asthma, recruited from a hospital respiratory clinic. Peak flow and a forced expiratory flow‐volume loop were measured and the patients were then given 1–1.5 mg.kg^−1^ effervescent diclofenac orally. Spirometry was repeated at 10, 20 and 30 min, a 15% decrease in results being considered a significant reduction in lung function. No patient demonstrated a consistent reduction in lung function of  > 15% during the study and there were no reports of wheezing or increased bronchodilator use after completion of the spirometry. In conclusion, we studied a group of genuine asthmatics and found no clinically significant incidence of bronchospasm with the use of a single therapeutic dose of diclofenac.