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Pharmacokinetics of intravenous diclofenac sodium in children

✍ Scribed by R. Korpela; K. T. Olkkola

Publisher
Springer
Year
1990
Tongue
English
Weight
299 KB
Volume
38
Category
Article
ISSN
0031-6970

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✦ Synopsis

Diclofenac sodium 0.5 mg/kg i.v. was given preoperatively to small children (age 4-6 y). Vt and total plasma clearance were higher than in adults but the elimination half-life was similar.

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Pharmacokinetics of intravenous chlorpheniramine in children
✍ John A. Thompson; Duane C. Bloedow; Fred H. Leffert πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 391 KB

The disposition of chlorpheniramine was examined in seven children, 6-14 years of age, following a O.l-mg/kg iv dose. Postinjection serum chlorpheniramine levels in each subject declined biexponentially, with the greatest intersubject variability occurring in the initial distribution of the drug. Th