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Use of cyclodextrins in chiral discrimination by NMR spectroscopy: An example of atropisomerism

✍ Scribed by Alan F. Casy

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
171 KB
Volume
31
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The influence of α‐, β‐ and γ‐cyclodextrin (CD) on the ^1^H NMR spectrum of the muscarinic antagonist telenzepine dihydrochloride in D~2~O is reported. Duplication of thienyl‐H and thienyl‐Me signals was observed in the presence of β‐ and γ‐CD, with regard to the minor amido conformer in the former case and both major and minor amido conformers in the latter case. Use of CDs in chiral discrimination by NMR is now well known; the present results provide the first example of their application to an atropisomeric example.

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