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Application of cyclodextrins to chiral analysis by 1H NMR spectroscopy

✍ Scribed by A. F. Casy; A. D. Mercer

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 700 KB
Volume: 26
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260260908

No coin nor oath required. For personal study only.

✦ Synopsis

The influence of inclusion complex formation between cyclodextrins (chiefly the 8-polymer) and a variety of chiral antihistaminic and analgesic agents on the 'H NMR features of both guest and host partners is reported. In many cases equivalent protons of antipodes give resonances which differ in chemical shift after inclusion, and the potential value of the data to chiral analysis and to elucidation of the structures of the inclusion complexes is demonstrated. KEY WORDS Inclusion complexes Cyclodextrins Chiral antihistamines Chiral analgesics Chiral analysis

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