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Use of conditional distributions in the analysis of ion channel recordings

✍ Scribed by D. Petracchi; M. Barbi; M. Pellegrini; M. Pellegrino; A. Simoni

Publisher
Springer
Year
1991
Tongue
English
Weight
784 KB
Volume
20
Category
Article
ISSN
1432-1017

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✦ Synopsis

A method to test the Markov nature of ion channel gating is proposed. It makes use of singly and doubly conditional distributions. The application of this method to recordings from single BK channels provides evidence that at least two states of the underlying kinetic scheme are left at a constant rate. Moreover, the probabilities, when leaving a state, of reaching another given state are shown to be constant for all the states of the system.

πŸ“œ SIMILAR VOLUMES

The Akaike information criterion (AIC) i
The Akaike information criterion (AIC) is not a sufficient condition to determine the number of ion channel states from single channel recordings
✍ Larry S. Liebovitch; Tibor I. TΓ³th πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 453 KB

The Akaike information criterion (AIC) and other criteria that trade off the goodness-of-fit against the number of parameters have been used to determine the number of ion channel states from single channel recordings. We show that, in general, such criteria are not valid. This is illustrated by an