The Akaike information criterion (AIC) is not a sufficient condition to determine the number of ion channel states from single channel recordings
✍ Scribed by Larry S. Liebovitch; Tibor I. Tóth
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 453 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0887-4476
No coin nor oath required. For personal study only.
✦ Synopsis
The Akaike information criterion (AIC) and other criteria that trade off the goodness-of-fit against the number of parameters have been used to determine the number of ion channel states from single channel recordings. We show that, in general, such criteria are not valid. This is illustrated by an elementary example in which the AIC yields an incorrect result. The implications of these findings for the discrimination of different kinetic models of ion channels are discussed.
Kinetics, Statistics, Asymptotic information criterion
USE OF THE AKAIKE INFORMATION CRITERION (AIC)
The patch-clamp techni ue (Hamill et al., 1981) can resolve the current throug 7l a single ion channel. The