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Use of Benzofuran for Concomitant Protection of Aldehyde and Phenol Groups in the Preparation of Mycophenolic Acid Analogues

✍ Scribed by Fardis, Maria; Mertzman, Michael; Thomas, William; Kirschberg, Thorsten; Collins, Nicole; Polniaszek, Richard; Watkins, William J.


Book ID
127278693
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
89 KB
Volume
71
Category
Article
ISSN
0022-3263

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A useful method for the preparation of f
✍ AndrΓ© Pichette; Normand Voyer; RΓ©mi Larouche; Jean-Christophe Meillon πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 175 KB

Resin bound peptides can be cleaved from the Kaiser oxime resin using various oxygen nucleophiles (H20, CH3OH, PhCH2OH) with DBU. Fully protected peptide acids and esters are obtained rapidly and with good yields using this new method of cleavage.