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Use of ammonium aryl H-phosphonates in the preparation of nucleoside H-phosphonate building blocks

✍ Scribed by Vita Ozola; Colin B Reese; Quanlai Song

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
237 KB
Volume
37
Category
Article
ISSN
0040-4039

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Nucleoside H-Phosphonates are used directly in the synthesis of H-phosphonate linked deoxyoligonucleotides. A rapid and simplified procedure for the synthesis of deoxyoligonucleotides is described. Ribonucleoside H-phosphonate I. was introduced by Todd to prepare diribonucleotide 1 phosphate 4 (Sche