USE OF A STOCHASTIC MODEL FOR REPEATED BINARY ASSESSMENT

✍ Scribed by HABIB HASSANI; ALAN EBBUTT

• Book ID: 102651327
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 583 KB
• Volume: 15
• Category: Article
• ISSN: 0277-6715
• DOI: 10.1002/(sici)1097-0258(19961215)15:23<2617::aid-sim376>3.0.co;2-p

✦ Synopsis

We discuss a stochastic model appropriate for binary data in clinical studies where assessments are made at various nominal times during a treatment phase. The model is then applied to data on headache relief, nausea and photophobia/phonophobia in a migraine study. The transition rates and probabilities during the initial 240 minutes after treatment administration are derived using the method of maximum likelihood. The results are then compared with analysis at each nominal time point. Stochastic modelling is considered more appropriate for the analysis of repeated binary assessments than analysis at each nominal time since each patient's assessments are modelled simultaneously.