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Use of 3-azabicyclo[3.2.2.]nonane in the mannich reaction III. γ-amino tertiary alcohols

✍ Scribed by C. Dewitt Blanton Jr.; W. Lewis Nobles

Publisher
John Wiley and Sons
Year
1964
Tongue
English
Weight
327 KB
Volume
53
Category
Article
ISSN
0022-3549

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✦ Synopsis

methyl group in the 6 position of the tetracycline molecule. While DMCT has not been reported to have been tested in the chemotherapy of leptospirosis, chlortetracycline (CT) , oxytetracycline (OT). and tetracycline (TC) have been effective against experimental leptospiral infections in chick embryos, hamsters, guinea pigs, dogs, and cattle (5-10). Furthermore, Howarth (11) was successful in clearing swine carriers of Leptospira purnona with CT and OT, while Stoenner and his associates (12) eliminated L. ballum from a naturally infected colony of mice using CT.

📜 SIMILAR VOLUMES

Efficient Synthesis of the Azabicyclo[3.
Efficient Synthesis of the Azabicyclo[3.3.1]nonane Ring System in the Alkaloid Methyllycaconitine Using Bis(alkoxymethyl)alkylamines as Aminoalkylating Agents in a Double Mannich Reaction
✍ Margaret A. Brimble; Constanze Brocke 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB

## Abstract The double Mannich reaction of cyclic β‐keto esters with bis(alkoxymethyl)alkylamines provides an efficient and versatile method for the construction of azabicyclo[3.3.1]nonanes and azabicyclo[3.2.1]octanes. The optimum conditions for efficient reaction involve use of the activator tric